Piezoelectric Analgesia Blocks Cancer‐Induced Bone Pain
Yifei Yin, Peiran Zhao, Xianyun Xu, Bangguo Zhou, Jian Chen, Xingwu Jiang, Yanyan Liu, Yelin Wu, Wenwen Yue, Huixiong Xu, Wenbo Bu
Abstract
Abstract The manipulation of cell surface receptors’ activity will open a new frontier for drug development and disease treatment. However, limited by the desensitization of drugs, effective physical intervention strategy remains challenging. Here, the controllable internalization of transient receptor potential vanilloid 1 (TRPV1) on neural cells by local piezoelectric field is reported. Single‐cell‐level local electric field is construct by synthesizing piezoelectric BiOIO 3 nanosheets (BIONSs). Upon a mild ultrasound of 0.08 W cm −2 , an electric field of 15.29 µV is generated on the surface of BIONSs, further inducing TRPV1 internalization in 5 min. The as‐downregulated TRPV1 expression results in the reduction of Ca 2+ signal in a spinal neuron and the inhibition of the activity of wide range dynamic neurons, therefore effectively preventing the transmission of cancer‐induced bone pain (CIBP). This strategy not only charts a new course for CIBP alleviation, but also introduces a promising nanotechnology for regulating cell surface receptors, showing significant potential in neuropathological and receptor‐related diseases.