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Design, synthesis and biological evaluation of novel N-(3-amino-4-methoxyphenyl)acrylamide derivatives as selective EGFRL858R/T790M kinase inhibitors

Shi Ding, Xiaoyong Dong, Ziye Gao, Xiangshan Zheng, Jingchao Ji, Mingjuan Zhang, Fang Liu, Shuang Wu, Min Li, Wenshan Song, Jiwei Shen, Wenwen Duan, Ju Liu, Ye Chen

2021Bioorganic Chemistry14 citationsDOI

Topics & Concepts

ChemistryA549 cellIC50KinasePharmacophoreBiochemistryIn vitroLung Cancer Treatments and MutationsCancer therapeutics and mechanismsQuinazolinone synthesis and applications
Design, synthesis and biological evaluation of novel N-(3-amino-4-methoxyphenyl)acrylamide derivatives as selective EGFRL858R/T790M kinase inhibitors | Litcius