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DCE-MRI of Brain Fluid Barriers: <i>In Vivo</i> Water Cycling at the Human Choroid Plexus

Valerie C. Anderson, Ian Tagge, Aaron Doud, Xin Li, Charles S. Springer, Joseph F. Quinn, Jeffrey Kaye, Katherine Wild, William D. Rooney

2021Tissue Barriers15 citationsDOIOpen Access PDF

Abstract

], but shows no difference between CI and CN individuals or association with cognitive performance. Our findings suggest that the CP water efflux rate constant is associated with cognitive dysfunction and shows an age-related decline in later life, consistent with the metabolic disturbances that characterize brain aging.

Topics & Concepts

Choroid plexusIn vivoCerebrospinal fluidMedicineHuman brainAnatomyPathologyBiologyNeuroscienceInternal medicineCentral nervous systemBiotechnologyAdvanced MRI Techniques and ApplicationsMRI in cancer diagnosis