Human Cytomegalovirus UL7, miR-US5-1, and miR-UL112-3p Inactivation of FOXO3a Protects CD34 <sup>+</sup> Hematopoietic Progenitor Cells from Apoptosis
Meaghan H. Hancock, Lindsey B. Crawford, Wilma Perez, Hillary M. Struthers, Jennifer Mitchell, Patrizia Caposio
Abstract
Human cytomegalovirus (HCMV) causes serious disease in immunocompromised individuals and is a significant problem during transplantation. The virus can establish a latent infection in CD34 + hematopoietic progenitor cells (HPCs) and periodically reactivate to cause disease in the absence of an intact immune system.
Topics & Concepts
CD34BiologyHaematopoiesisHuman cytomegalovirusProgenitor cellmicroRNAApoptosisCell biologyVirologyStem cellCancer researchVirusGeneGeneticsCytomegalovirus and herpesvirus researchMicroRNA in disease regulationImmune Cell Function and Interaction