Metabolic physiology and skeletal muscle phenotypes in male and female myoglobin knockout mice
Kikumi D. Ono‐Moore, I. Mark Olfert, Jennifer M. Rutkowsky, Sree V. Chintapalli, Brandon Willis, Michael L. Blackburn, David Williams, Juliana O’Reilly, Todd Tolentino, K. C. Kent Lloyd, Sean H. Adams
Abstract
The roles of myoglobin remain to be elaborated. We address sexual dimorphism in terms of outcomes in response to the loss of myoglobin in knockout mice and perform, for the first time, a series of comprehensive metabolic studies under conditions in which fat is mobilized (high-fat diet, cold). The results highlight that myoglobin is not necessary and sufficient for maintaining oxidative metabolism and point to alternative roles for this protein in muscle and heart.
Topics & Concepts
Internal medicineEndocrinologyRespiratory exchange ratioSoleus muscleBiologySkeletal muscleGlucose homeostasisMyoglobinInsulinThermogenesisCarbohydrate metabolismAdipose tissueInsulin resistanceBiochemistryMedicineHeart rateBlood pressureAdipose Tissue and MetabolismMuscle metabolism and nutritionIon channel regulation and function