The inositol pyrophosphate 5-InsP <sub>7</sub> drives sodium-potassium pump degradation by relieving an autoinhibitory domain of PI3K p85α
Alfred C. Chin, Zhe Gao, Andrew M. Riley, David Furkert, Christopher Wittwer, Amit K. Dutta, Tomás Rojas, Evan R. Semenza, Robin A. Felder, Jennifer L. Pluznick, Henning J. Jessen, Dorothea Fiedler, Barry V. L. Potter, Solomon H. Snyder, Chenglai Fu
Abstract
5-InsP 7 is an endogenous negative regulator of Na + /K + -ATPase.
Topics & Concepts
EndocytosisATPaseCell biologyBiochemistryChemistryInositolBiologyBiophysicsReceptorEnzymeCellular transport and secretionIon Transport and Channel RegulationCalcium signaling and nucleotide metabolism