The clinical spectrum of aspergillosis in chronic obstructive pulmonary disease
Akaninyene Otu, Chris Kosmidis, Alexander G. Mathioudakis, Chibuike Ibe, David W. Denning
Abstract
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. In this review, we present the clinical spectrum and pathogenesis of syndromes caused by Aspergillus in COPD namely invasive aspergillosis (IA), community-acquired Aspergillus pneumonia, chronic pulmonary Aspergillosis and Aspergillus sensitisation. Some of these entities are clearly linked to COPD, while others may coexist, but are less clearly liked directly to COPD. We discuss current uncertainties as these pertain to IA in COPD cohorts and explore areas for future research in this field.
Topics & Concepts
COPDPulmonary diseaseAspergillusAspergillosisMedicineIntensive care medicinePneumoniaDiseasePathogenesisPulmonary aspergillosisCause of deathBroad spectrumImmunologyPathologyInternal medicineMicrobiologyBiologyCombinatorial chemistryChemistryAntifungal resistance and susceptibilityFungal Infections and StudiesRespiratory and Cough-Related Research