Various synthesis and biological evaluation of some tri -tetra-substituted imidazoles derivatives: A review
Abdeljalil Hamdi, Walid Daoudi, Mohamed Aaddouz, Mohamed Azzouzi, Hassan Amhamdi, Abdellah Elyoussfi, Abdelmalik El Aatiaoui, Dakeshwar Kumar Verma, Mohamed Abboud, M’hamed Ahari
Abstract
The imidazole nucleus represents a significant group of heterocyclic molecules with diverse significance in the modern world due to its exploration potential and various pharmacological applications. The relevance of imidazole and its derivatives has gained popularity in recent years, especially in the production of commercial drugs and the treatment of various conditions. The imidazole nucleus is present in many natural compounds and widely distributed in essential amino acids, such as L-histidine, whose derivatives exhibit powerful pharmacological properties. In this review, we delve into the historical timeline and development of synthetic pathways for tri- and tetra-substituted imidazoles used in the renowned Radziszewski reaction. Furthermore, we explore various bacteriological applications documented in the literature, as well as current advances in preclinical approaches to imidazole-based drug discovery. Tri- or tetra-substituted imidazole derivatives show strong potential for new synthesis methods, such as reflux or microwave, as well as various biological activities.