Controversies around the function of LARP1
Andrea J. Berman, Carson C. Thoreen, Zinaida Dedeić, James Chettle, Philippe P. Roux, Sarah P. Blagden
Abstract
The RNA-binding protein LARP1 has generated interest in recent years for its role in the mTOR signalling cascade and its regulation of terminal oligopyrimidine (TOP) mRNA translation. Paradoxically, some scientists have shown that LARP1 represses TOP translation while others that LARP1 activates it. Here, we present opinions from four leading scientists in the field to discuss these and other contradictory findings.
Topics & Concepts
BiologyTranslation (biology)Function (biology)Messenger RNAComputational biologyCell biologyGeneticsGeneRNA Research and SplicingRNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer