Total Synthesis of the Potent and Broad-Spectrum Antibiotics Amycolamicin and Kibdelomycin
Shaoqiang Yang, Chenglong Chen, Jie Chen, Chao Li
Abstract
The complex and intriguing structures of the antibiotics amycolamicin and kibdelomycin are herein confirmed through total synthesis. Careful titration of the synthetic products reveals that kibdelomycin is the salt form of amycolamicin. This synthesis employs a highly convergent strategy, which provides a modular approach for further SAR studies of this class of antibiotics.
Topics & Concepts
ChemistryAntibioticsTotal synthesisBroad spectrumSalt (chemistry)Combinatorial chemistryStereochemistryOrganic chemistryBiochemistryMicrobial Natural Products and BiosynthesisCarbohydrate Chemistry and SynthesisAlkaloids: synthesis and pharmacology