Sexual dimorphism of circadian liver transcriptome
A. A. Astaf’ev, Volha Mezhnina, Allan Poe, Peng Jiang, Roman V. Kondratov
Abstract
(AL) and 30% caloric restriction (CR) diets. We found that AL female mice had a larger number of oscillating genes than male mice, and the portion of the transcriptome with sex-specific rhythms displayed phase difference. We found that CR increased the number of oscillating genes in both sexes and strongly synchronized the transcriptome without complete elimination of sex dimorphism in rhythms. Sex also had an effect on the response of the rhythms to CR. Gene ontology analysis revealed sex-specific signatures in metabolic pathways, which suggests a complex interaction of sex, circadian rhythms, and diet.
Topics & Concepts
Sexual dimorphismTranscriptomeCircadian rhythmBiologyCircadian clockPhysiologyEndocrinologyGeneticsGene expressionGeneCircadian rhythm and melatoninGenetics, Aging, and Longevity in Model OrganismsDietary Effects on Health