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A spatial architecture-embedding HLA signature to predict clinical response to immunotherapy in renal cell carcinoma

Lisa Kinget, Stefan Naulaerts, Jannes Govaerts, Isaure Vanmeerbeek, Jenny Sprooten, Raquel S. Laureano, Nikolina Dubroja, Gautam Shankar, Francesca M. Bosisio, Eduard Roussel, Annelies Verbiest, Francesca Finotello, Markus Außerhofer, Diether Lambrechts, Bram Boeckx, Agnieszka Woźniak, Louis Boon, Johan Kerkhofs, Jessica Zucman‐Rossi, Maarten Albersen, Marcella Baldewijns, Benoit Beuselinck, Abhishek D. Garg

2024Nature Medicine49 citationsDOIOpen Access PDF

Topics & Concepts

Immune checkpointImmunotherapyMedicineProinflammatory cytokineImmunologyImmune systemBiologyOncologyInflammationSingle-cell and spatial transcriptomicsCancer Immunotherapy and BiomarkersCancer Genomics and Diagnostics
A spatial architecture-embedding HLA signature to predict clinical response to immunotherapy in renal cell carcinoma | Litcius