Determination of hydroquinone and benzoquinone in pharmaceutical formulations: critical considerations on quantitative analysis of easily oxidized compounds
Olívia Brito de Oliveira Moreira, Lucas V. de Faria, Renato Camargo Matos, Karine Braga Enes, Mara Rúbia Costa Couri, Marcone Augusto Leal de Oliveira
Abstract
; recovery mean value of 100% with 0.22% RSD). A gel topical formulation containing 4% (w/w) hydroquinone was analyzed through the developed method for determination of dosage and oxidation traces, and a content of 3.53 ± 0.095% (w/w) was found with no indications of degradation.
Topics & Concepts
HydroquinoneChemistrySupporting electrolyteBenzoquinoneMethanolRedoxElectrolyteChromatographyGlassy carbonElectrodeElectrochemistryCyclic voltammetryOrganic chemistryPhysical chemistryBioactive Compounds and Antitumor AgentsEssential Oils and Antimicrobial ActivityPharmacological Effects of Natural Compounds