M6PR- and EphB4-Rich Exosomes Secreted by Serglycin-Overexpressing Esophageal Cancer Cells Promote Cancer Progression
Dongdong Yan, Di Cui, Yun Zhu, Cecilia Ka Wing Chan, Chung Hang Jonathan Choi, Tengfei Liu, Nikki P.Y. Lee, Simon Law, Sai Wah Tsao, Stephanie Ma, Annie Lai Man Cheung
Abstract
expression affected the viability and migration of ESCC cells. Both M6PR and EphB4 expression levels were positively correlated with that of SRGN in the serum of patients with ESCC. High level of serum M6PR was associated with poor overall survival rates. Taken together, this study presents the first proof that exosomal M6PR and EphB4 play essential roles in tumor angiogenesis and malignancy, and that serum M6PR is a novel prognostic marker for ESCC patients.
Topics & Concepts
MicrovesiclesExosomeCancer researchAngiogenesisBiologyMetastasisDownregulation and upregulationParacrine signallingMMP2In vitroCancerReceptorCell biologymicroRNABiochemistryGeneGeneticsExtracellular vesicles in diseaseCancer-related molecular mechanisms researchCircular RNAs in diseases