Construction of biocatalytic cascades for the synthesis of benzylisoquinoline alkaloids from <i>p</i>-coumaric acid derivatives and dopamine
Mingtao Zhao, Ziqing Qin, Abdullah Abdullah, Yi Xiao
Abstract
Biocatalytic cascades were developed to synthesize 15 benzylisoquinoline alkaloids in excellent ee values from dopamine and p -coumaric acid derivatives.
Topics & Concepts
BenzylisoquinolineChemistryDopamineOrganic chemistryCoumaric acidp-Coumaric acidStereochemistryBiochemistryBiologyEnzymeFerulic acidBiosynthesisNeuroscienceAntioxidantEnzyme Catalysis and ImmobilizationChemical synthesis and alkaloidsCarbohydrate Chemistry and Synthesis