Ni-Catalyzed Reductive Fluoroalkylacylation of Alkynes for the Steroselective Synthesis of Fluoroalkylated Enones
Zhuzhu Zhang, Jia-Jia Lei, Xiaohong Zhang, Xiaohong Zhang, Xing‐Guo Zhang, Xing‐Guo Zhang, Hai‐Yong Tu
Abstract
A Ni-catalyzed three-component reductive fluoroalkylacylation of alkynes with fluoroalkyl halides and acyl chlorides is presented. This dicarbofunctionalization provides an efficient method for the synthesis of fluoroalkyl-incorporated enones under mild conditions with high yields and excellent regioselectivity and stereoselectivity.
Topics & Concepts
ChemistryRegioselectivityStereoselectivityCatalysisHalideCombinatorial chemistryMedicinal chemistryOrganic chemistryFluorine in Organic ChemistryCatalytic C–H Functionalization Methods