Towards the stable chelation of radium for biomedical applications with an 18-membered macrocyclic ligand
Diane S. Abou, Nikki A. Thiele, Nicholas T. Gutsche, Alexandria Villmer, Hanwen Zhang, Joshua J. Woods, Kwamena E. Baidoo, Freddy E. Escorcia, Justin J. Wilson, Daniel L.J. Thorek
Abstract
to metastases outside of the bone using functionalized chelators, marking a significant expansion of the therapeutic utility of this radiometal in the clinic.
Topics & Concepts
ChelationRadiumLigand (biochemistry)ChemistryCombinatorial chemistryChelation therapyStereochemistryRadiochemistryOrganic chemistryBiochemistryReceptorRadiopharmaceutical Chemistry and ApplicationsLanthanide and Transition Metal ComplexesRadioactive element chemistry and processing