Synthesis, biological evaluation and molecular docking studies of novel 1,2,3-triazole-quinazolines as antiproliferative agents displaying ERK inhibitory activity
Paulo Sérgio Gonçalves Nunes, Gabriel da Silva, Sofia Nascimento, Susimaire P. Mantoani, Peterson de Andrade, Emerson Soares Bernardes, Daniel Fábio Kawano, Andréia Machado Leopoldino, Ivone Carvalho
Topics & Concepts
ChemistryPharmacophoreKinaseMAPK/ERK pathwayDocking (animal)Viability assayCell cycle checkpointStereochemistryBiochemistryCell cycleIn vitroCellNursingMedicineMelanoma and MAPK PathwaysQuinazolinone synthesis and applicationsSynthesis and biological activity