Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer
Dig Bijay Mahat, Heena Kumra, Sarah A Castro, Emily Metcalf, Kim B. Nguyen, Ryo Morisue, William W. Ho, Ivy Chen, Brandon M. Sullivan, Leon Yim, Arundeep Singh, Jiayu Fu, Sean K. Waterton, Yu‐Chi Cheng, Enrico Moiso, Vikash P. Chauhan, Hernandez Moura Silva, Stefani Spranger, R. K. Jain, Phillip A. Sharp
Topics & Concepts
BiologyPancreatic cancerCancer researchChemokineImmune systemEnhancerMutantImmune checkpointCancerImmunologyImmunotherapyGene expressionGeneticsGenePancreatic and Hepatic Oncology ResearchCancer Immunotherapy and BiomarkersCancer-related Molecular Pathways