Synthesis of <sup>18</sup>O-labelled alcohols from unlabelled alcohols
Rhydian H. Beddoe, Daniel C. Edwards, Louis E. Goodman, Helen F. Sneddon, Ross M. Denton
Abstract
The synthesis of primary, secondary and tertiary 18O-enriched alcohols from readily available 16O-alcohols via a Mitsunobu esterification and hydrolysis is described. The method is further exemplified in the labelling of the active pharmaceutical ingredient, dropropizine and is shown to be tolerant of modern, separation friendly Mitsunobu reagents.
Topics & Concepts
ChemistryHydrolysisPrimary (astronomy)AlcoholMitsunobu reactionTertiary alcoholsOrganic chemistryPrimary alcoholMedicinal chemistryRadiochemistryMethanolAstronomyPhysicsChemical Reactions and IsotopesAmino Acid Enzymes and MetabolismMass Spectrometry Techniques and Applications