Late-Stage C–H Functionalization of Nimesulide via (Nimesulide)(3,5-dimethylisoxazol-4-yl)iodonium Salt Formation
Dmitry I. Bugaenko, Alexander V. Karchava
Abstract
Abstract The reaction of N-methylated nimesulide with Koiser’s reagent based on 4-iodo-3,5-dimethylisoxazole (DMIX-I(OH)OTs) yielded the corresponding iodonium salt. Subsequent interaction of this salt with S-, O-, and N-nucleophiles gave functionalized derivatives of nimesulide.
Topics & Concepts
NimesulideChemistrySalt (chemistry)Surface modificationStage (stratigraphy)Medicinal chemistryCombinatorial chemistryOrganic chemistryNuclear chemistryBiochemistryPaleontologyBiologyPhysical chemistryCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsSynthesis and Catalytic Reactions