A subset of follicular helper-like MAIT cells can provide B cell help and support antibody production in the mucosa
Owen Jensen, Shubhanshi Trivedi, Jeremy D. Meier, Keke C. Fairfax, J. Scott Hale, Daniel T. Leung
Abstract
–specific IgA responses. Our data demonstrate the capacity of MAIT cells to participate in adaptive immune responses and suggest that MAIT cells may be potential targets for mucosal vaccines.
Topics & Concepts
Germinal centerBiologyImmunologyAdoptive cell transferCD40Cytotoxic T cellPopulationB cellFollicular dendritic cellsInnate lymphoid cellAcquired immune systemAntibodyT cellImmune systemAntigen-presenting cellMedicineIn vitroEnvironmental healthBiochemistryImmune Cell Function and InteractionT-cell and B-cell ImmunologyIL-33, ST2, and ILC Pathways