Highly-fluorescent BODIPY-functionalised metallacages as drug delivery systems: synthesis, characterisation and cellular accumulation studies
Brech Aikman, Riccardo Bonsignore, Ben Woods, Daniel Doellerer, Riccardo Scotti, Claudia Schmidt, Alexandra A. Heidecker, Alexander Pöthig, Edward J. Sayers, Arwyn T. Jones, Angela Casini
Abstract
⊂CG1·BF4] complex in the various cell lines, which correlate with its different intracellular localisation profiles. The obtained preliminary results provide a new hypothesis on how the subcellular localisation of the cage affects the cisplatin intracellular release.
Topics & Concepts
IntracellularChemistryBODIPYCancer cellDrug deliveryBiophysicsConfocal microscopyCytotoxicityCombinatorial chemistryBiochemistryFluorescenceCancerOrganic chemistryIn vitroCell biologyBiologyGeneticsPhysicsQuantum mechanicsSupramolecular Chemistry and ComplexesAdvanced biosensing and bioanalysis techniquesSupramolecular Self-Assembly in Materials