Novel Pyrimidine Derivatives Bearing a 1,3,4-Thiadiazole Skeleton: Design, Synthesis, and Antifungal Activity
Nianjuan Pan, Chunyi Liu, Ruirui Wu, Qiang Fei, Wenneng Wu
Abstract
In this study, twenty novel pyrimidine derivatives bearing a 1,3,4-thiadiazole skeleton were designed and synthesized. Then their antifungal activity against Botrytis cinereal ( B. cinereal ), Botryosphaeria dothidea ( B. dothidea ), and Phomopsis sp. were determined using the poison plate technique. Biological test results showed that compound 6h revealed lower EC 50 values (25.9 and 50.8 μg/ml) on Phompsis sp. than those of pyrimethanil (32.1 and 62.8 μg/ml).
Topics & Concepts
Botryosphaeria dothideaPyrimidineAntifungalBotrytis cinereaPyrimethanilChemistrySkeleton (computer programming)FungicideStereochemistryBotanyBiologyMicrobiologyAnatomyFungal Plant Pathogen ControlPlant chemical constituents analysisSynthesis and biological activity