The role of m6A methylation in therapy resistance in cancer
Hengzhao Zhuang, Bo Yu, Dan Tao, Xiaoyan Xu, Yijun Xu, Jian Wang, Yang Jiao, Lili Wang
Abstract
Cancer therapy resistance is the main cause of cancer treatment failure. The mechanism of therapy resistance is a hot topic in epigenetics. As one of the most common RNA modifications, N6-methyladenosine (m6A) is involved in various processes of RNA metabolism, such as stability, splicing, transcription, translation, and degradation. A large number of studies have shown that m6A RNA methylation regulates the proliferation and invasion of cancer cells, but the role of m6A in cancer therapy resistance is unclear. In this review, we summarized the research progress related to the role of m6A in regulating therapy resistance in cancers.
Topics & Concepts
BiologyEpigeneticsMethylationCancerRNA methylationRNACancer researchRNA splicingCancer therapyMechanism (biology)Epigenetic therapyDNA methylationTranscription (linguistics)Targeted therapyBioinformaticsGeneticsGene expressionGeneMethyltransferasePhilosophyLinguisticsEpistemologyRNA modifications and cancerCancer-related gene regulationCancer-related molecular mechanisms research