Strategies for Taste Masking of Orodispersible Dosage Forms: Time, Concentration, and Perception
Ji Yu, Jin Xie, Huijuan Xie, Qi Hu, Zhenfeng Wu, Xinfu Cai, Guo Zhiping, Junzhi Lin, Li Han, Dingkun Zhang
Abstract
Orodispersible dosage forms, characterized as quick dissolving and swallowing without water, have recently gained great attention from the pharmaceutical industry, as these forms can satisfy the needs of children, the elderly, and patients suffering from mental illnesses. However, poor taste by thorough exposure of the drugs' dissolution in the oral cavity hinders the effectiveness of the orodispersible dosage forms. To bridge this gap, we put forward three taste-masking strategies with respect to the intensity of time, concentration, and perception. We further investigated the raw material processing, the composition of auxiliary material, formulation techniques, and process control in each strategy and drew conclusions about their effects on taste masking.