Light-activated controlled release of camptothecin by engineering porous materials: the <i>ship in a bottle</i> concept in drug delivery
Eva Rivero‐Buceta, Mirela Encheva, B. Cech, Eduardo Fernández, Germán Sastre, Christopher C. Landry, Pablo Botella
Abstract
photoisomerization, which allowed the prodrug to be delivered safely and its release to be triggered precisely at the region of interest. Finally, the intracellular release and cytotoxic activity of this novel drug delivery system has been validated in several human cell lines, confirming the ability of this system to accurately control the release of the camptothecin prodrug.
Topics & Concepts
CamptothecinDrug deliveryProdrugBottleMaterials scienceNanotechnologyMesoporous silicaDrugPorosityNanoparticleMesoporous materialChemical engineeringChemistryOrganic chemistryCatalysisPharmacologyComposite materialEngineeringMedicineBiochemistryPhotochromic and Fluorescence ChemistryNanoplatforms for cancer theranosticsPorphyrin and Phthalocyanine Chemistry