Hydrazylpyridine salicylaldehyde–copper(<scp>ii</scp>)–1,10-phenanthroline complexes as potential anticancer agents: synthesis, characterization and anticancer evaluation
Yating Chen, Zhilin Ke, Lingyu Yuan, Meixiang Liang, Shu‐Hua Zhang
Abstract
both ATP diminution and mitophagy pathways. Finally, Cugdupt8 demonstrated high efficacy and no obvious cytotoxicity in A549 tumor-bearing mice. This study thus helps evaluate the potential of the hydrazylpyridine salicylaldehyde-copper(II)-1,10-phenanthroline compounds for cisplatin-resistant tumor therapy.
Topics & Concepts
SalicylaldehydePhenanthrolineCopperChemistryCharacterization (materials science)Combinatorial chemistryStereochemistryNanotechnologyOrganic chemistryMaterials scienceSchiff baseMetal complexes synthesis and propertiesMagnetism in coordination complexesLanthanide and Transition Metal Complexes