Antitumor effects of iPSC-based cancer vaccine in pancreatic cancer
Xiaoming Ouyang, Yu Liu, Yang Zhou, Jing Guo, Tzu-Tang Wei, Chun Liu, Bomi Lee, Binbin Chen, Angela Zhang, Kerriann M. Casey, Lin Wang, Nigel G. Kooreman, Aida Habtezion, Edgar G. Engleman, Joseph C. Wu
Abstract
T regulatory cells, and prevented tumor formation in 75% of pancreatic ductal adenocarcinoma (PDAC) mice. We demonstrate that shared gene expression profiles of "iPSC-cancer signature genes" and others are overexpressed in mouse and human iPSC lines, PDAC cells, and multiple human solid tumor types compared with normal tissues. These results support further studies of iPSC vaccination in PDAC in preclinical and clinical models and in other cancer types that have low mutational burdens.
Topics & Concepts
BiologyPancreatic cancerInduced pluripotent stem cellCancer researchCytotoxic T cellCancer immunotherapyCD8CancerCancer cellTranscriptomeImmune systemImmunotherapyAdenocarcinomaImmunologyGeneGene expressionGeneticsIn vitroEmbryonic stem cellImmunotherapy and Immune ResponsesCAR-T cell therapy researchCancer Immunotherapy and Biomarkers