suPAR, a Circulating Kidney Disease Factor
Changli Wei, Ryan Spear, Eunsil Hahm, Jochen Reiser
Abstract
Urokinase plasminogen activator receptor (uPAR) is a multifaceted, GPI-anchored three-domain protein. Release of the receptor results in variable levels of soluble uPAR (suPAR) in the blood circulation. suPAR levels have been linked to many disease states. In this mini-review, we discuss suPAR as a key circulating molecule mediating kidney disease with a particular focus on differently spliced isoforms.
Topics & Concepts
SuPARUrokinase receptorReceptorGene isoformDiseasePlasminogen activatorKidneyMedicineImmunologyBiologyInternal medicineBiochemistryGeneRenal Diseases and GlomerulopathiesBlood Coagulation and Thrombosis MechanismsCoagulation, Bradykinin, Polyphosphates, and Angioedema