Ferroptosis of Immune Cells in Infection, Inflammation and Tumor Progression
Huihao Xu, Yanjun Lu, Qingwei Zeng, Xudong Zhu, Wenxian Guan, Song Liu
Abstract
Ferroptosis has been described as a unique form of programmed cell death. Its mechanism mainly involves iron metabolism disorders, lipid peroxidation and impaired antioxidant defense systems. The role of ferroptosis in infection, inflammation and tumor development has gained widespread attention. In particular, ferroptosis in immune cells significantly affects immune responses during disease progression. This review aims to summarize the advanced research progress of ferroptosis in different types of immune cells. It also discusses potential therapeutic targets and strategies to regulate ferroptosis, which may offer novel interventions for diseases, especially cancer.
Topics & Concepts
Immune systemInflammationCancer researchMechanism (biology)Tumor progressionImmunologyDiseaseGPX4MedicineBiologyLipid peroxidationProgrammed cell deathCellular metabolismCellTumor cellsTumor microenvironmentLipid metabolismOxidative stressImmunityImmunotherapyFerroptosis and cancer prognosisCancer Immunotherapy and BiomarkersCancer, Lipids, and Metabolism