Hypoxia-inducible factor (HIF)-3α2 serves as an endothelial cell fate executor during chronic hypoxia
Maciej Jaśkiewicz, Adrianna Moszyńska, Marcin Serocki, Jarosław Króliczewski, Sylwia Bartoszewska, James F. Collawn, Rafał Bartoszewski
Abstract
), a gene known to promote apoptosis. We also demonstrate that caspase 3/7 activity is elevated, supporting that the role of the HIF-3α2 isoform is to promote apoptosis. Furthermore, we provide evidence that HIF-3α2 is also expressed in seven other primary endothelial cell types, suggesting that this may be a common feature of HIF-3α2 in endothelial cells.
Topics & Concepts
Gene isoformHIF1AHypoxia-inducible factorsTranscription factorCell biologyBiologyApoptosisAlternative splicingHypoxia (environmental)HydroxylationMolecular biologyChemistryGeneBiochemistryOrganic chemistryEnzymeOxygenCancer, Hypoxia, and MetabolismRNA modifications and cancerCancer-related molecular mechanisms research