USP15 suppresses tumor immunity via deubiquitylation and inactivation of TET2
Leilei Chen, Matthew D. Smith, Lei Lv, Tadashi Nakagawa, Zhijun Li, Shao‐Cong Sun, Nicholas G. Brown, Yue Xiong, Yanping Xu
Abstract
in melanoma stimulates chemokine expression and TILs in a TET2-dependent manner, leading to increased response to immunotherapy and extended life span of tumor-bearing mice. These results reveal a previously unknown regulator of TET2 activity and suggest USP15 as a potential therapeutic target for immunotherapy of solid tumors.
Topics & Concepts
Cancer researchDeubiquitinating enzymeChemokineMelanomaBiologyImmunotherapyInterferonHaematopoiesisGeneImmunologyChemistryUbiquitinCell biologyInflammationImmune systemGeneticsStem cellEpigenetics and DNA MethylationAutophagy in Disease and TherapyImmune cells in cancer