Smart Layer-by-Layer Polymeric Microreactors: pH-Triggered Drug Release and Attenuation of Cellular Oxidative Stress as Prospective Combination Therapy
Edurne Marin, Neha Tiwari, Marcelo Calderón, José-Ramon Sarasua, Aitor Larrañaga
Abstract
from solution, protecting cells from oxidative stress, and release the model drug in acidic microenvironments. Accordingly, in this work, a polymeric microplatform is presented as an unexplored combinatorial approach applicable for multiple targets of inflammatory diseases, in order to perform controlled spatiotemporal enzymatic reactions and drug release in response to biologically relevant stimuli.
Topics & Concepts
Materials scienceLayer (electronics)MicroreactorOxidative stressNanotechnologyDrugAttenuationLayer by layerStress (linguistics)Oxidative phosphorylationChemical engineeringOrganic chemistryPharmacologyChemistryCatalysisBiochemistryMedicineEngineeringLinguisticsOpticsPhysicsPhilosophyNanoplatforms for cancer theranosticsPolymer Surface Interaction StudiesGraphene and Nanomaterials Applications