HIV-1 Vpr Induces Widespread Transcriptomic Changes in CD4 <sup>+</sup> T Cells Early Postinfection
Hélène Bauby, Christopher Ward, Rupert Hugh-White, Chad M. Swanson, Reiner Schulz, Caroline Goujon, Michael H. Malim
Abstract
T cells following HIV-1 infection; here, we provide a detailed examination of changes occurring in the first 24 h of infection. Importantly, we define the viral protein Vpr as essential for the changes observed at this early stage. This finding has significance for understanding the role of Vpr in infection and pathogenesis and also for interpreting previous transcriptomic analyses of HIV-1 infection.
Topics & Concepts
TranscriptomeBiologyDownregulation and upregulationGeneVirusVirologyGene expressionInnate immune systemIntrinsic immunityImmunityRegulation of gene expressionFunction (biology)Immune systemImmunologyCell biologyGeneticsHIV Research and TreatmentImmune Cell Function and InteractionT-cell and B-cell Immunology