Intelligent Supramolecular Nanoprodrug Based on Anionic Water-Soluble [2]Biphenyl-Extended-Pillar[6]arenes for Combination Therapy
Yue Ding, Wei Yu, Jian Wang, Yuxuan Ma, Chenwei Wang, Yang Wang, Bing Lü, Yong Yao
Abstract
An anionic water-soluble [2]biphenyl-extended-pillar[6]arenes modified with eight ammonium salt ions (AWBpP6) was successfully synthesized to establish a drug-drug conjugate supramolecular nanoprodrug (SNP) with a high drug-loading capacity. This SNP can generate a synergistic triple therapeutic effect of photodynamic therapy (PDT), photothermal therapy (PTT), and chemotherapy (CT; i.e., PDT-PTT-CT) with excellent biocompatibility.
Topics & Concepts
BiphenylPillarSupramolecular chemistryMaterials scienceWater solublePolymer chemistryOrganic chemistryMoleculeChemistryEngineeringStructural engineeringSupramolecular Chemistry and ComplexesSupramolecular Self-Assembly in MaterialsNanoplatforms for cancer theranostics