Induction of diverse T cell memory through antibody‐mediated activation in mice
Matthew Taylor, Mariana R. Brewer, Clifford S. Deutschman
Abstract
Recent studies have demonstrated that laboratory mice lack a robust repertoire of memory T cell. Administration of an anti-CD3ε activating antibody (clone 145-2C11) induces persistent CD4 and CD8 T cell memory in both lymphatic and solid organs while maintaining T cell responses and without increased anergy or altering innate immunity.
Topics & Concepts
Biologyclone (Java method)ImmunologyAntibodyCD8RepertoireT cellCell biologyImmunityMemory cellLymphatic systemCellMemory T cellImmunological memoryImmune systemGeneticsGeneAcousticsQuantum mechanicsPhysicsVoltageTransistorT-cell and B-cell ImmunologyImmune Cell Function and InteractionImmunotherapy and Immune Responses