Surmounting tumor resistance to metallodrugs by co-loading a metal complex and siRNA in nanoparticles
Hongzhi Qiao, Lei Zhang, Dong Fang, Zhenzhu Zhu, Weijiang He, Lihong Hu, Liuqing Di, Zijian Guo, Xiaoyong Wang
Abstract
RNA interference, and the therapeutic efficacy was significantly enhanced. The nanoparticles triggered a cellular autophagy that amplified the apoptotic signals, thus revealing a novel mechanism for antagonizing the resistance of copper complexes. In view of the extensive association of Bcl-2 protein with cancer resistance to chemotherapeutics, this strategy may be universally applicable for overcoming the ubiquitous drug resistance to metallodrugs.
Topics & Concepts
NanocarriersGene silencingRNA interferenceNanoparticleSmall interfering RNAChemistryNanotechnologyTumor cellsCancer researchRNAGeneBiologyMaterials scienceBiochemistryRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesMetal complexes synthesis and properties