Cryo-electron Microscopy Structure of the Acinetobacter baumannii 70S Ribosome and Implications for New Antibiotic Development
Christopher E. Morgan, Wei Huang, Susan D. Rudin, Derek J. Taylor, James E. Kirby, Robert A. Bonomo, Edward Yu
Abstract
Acinetobacter baumannii is a severe nosocomial threat largely due to its intrinsic antibiotic resistance and remarkable ability to acquire new resistance determinants. The bacterial ribosome serves as a major target for modern antibiotics and the design of new therapeutics. Here, we present cryo-EM structures of the A. baumannii 70S ribosome, revealing several unique species-specific structural features that may facilitate future drug development to combat this recalcitrant bacterial pathogen.
Topics & Concepts
Acinetobacter baumanniiRibosomeAntibioticsMicrobiologyAntibiotic resistanceHuman pathogenDrug resistanceBiologyDrug developmentPathogenComputational biologyBacteriaDrugGeneticsRNAPharmacologyGenePseudomonas aeruginosaRNA and protein synthesis mechanismsBacterial Genetics and BiotechnologyAntibiotic Resistance in Bacteria