Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture
Khushboo Bafna, Kris M. White, Balasubramanian Harish, Romel Rosales, Theresa A. Ramelot, Thomas Acton, Elena Moreno, Thomas Kehrer, Lisa Miorin, Catherine A. Royer, Adolfo Garcı́a-Sastre, Robert M. Krug, G.T. Montelione
Abstract
do not synergize with remdesivir.
Topics & Concepts
ProteaseVirologyNS3Viral replicationVero cellNS2-3 proteaseHepatitis C virusVirusBiologyProtease inhibitor (pharmacology)CoronavirusChemistryEnzymeMedicineBiochemistryCoronavirus disease 2019 (COVID-19)Viral loadInfectious disease (medical specialty)Antiretroviral therapyPathologyDiseaseHepatitis C virus researchSARS-CoV-2 and COVID-19 ResearchInfluenza Virus Research Studies