Kinomic profile in patient-derived glioma cells during hypoxia reveals c-MET-PI3K dependency for adaptation
Hong Sheng Cheng, Charlie Marvalim, Pengcheng Zhu, Cheng Lui Daniel Law, Zhi Yan Jeremy Low, Yuk Kien Chong, Beng Ti Ang, Carol Tang, Nguan Soon Tan
Abstract
Thus, our "bench to bedside (the use of patient-derived GPCs and xenografts for basic research) and back (validation with independent glioblastoma transcriptome databases)" analysis unravels the novel therapeutic indications of c-MET and PI3K/Akt inhibitors for the treatment of glioblastoma, and potentially other cancers, in the hypoxic tumor microenvironment.
Topics & Concepts
PI3K/AKT/mTOR pathwayKinomeHypoxia (environmental)Protein kinase BCancer researchTranscriptomeTemozolomideTumor microenvironmentGliomaKinaseBiologyPharmacologyMedicineSignal transductionChemistryCell biologyGene expressionBiochemistryGeneOxygenOrganic chemistryTumor cellsCancer, Hypoxia, and MetabolismGlioma Diagnosis and Treatmentinterferon and immune responses