Pharmacokinetic and Pharmacodynamic Profiling of Minocycline for Injection following a Single Infusion in Critically Ill Adults in a Phase IV Open-Label Multicenter Study (ACUMIN)
Thomas P. Lodise, Scott Van Wart, Zoë Sund, Adam Bressler, Akram Khan, Amy T. Makley, Yasir Hamad, Robert A. Salata, Fernanda P. Silveira, Matthew Sims, Badih A. Kabchi, Mohamed Saad, Carrie Brown, Randolph E. Oler, Vance G. Fowler, Richard G. Wunderink
Abstract
Intravenous (i.v.) minocycline is increasingly used to treat infections caused by multidrug-resistant (MDR) Acinetobacter baumannii . Despite its being approved nearly 50 years ago, published information on its pharmacokinetic (PK) profile is limited. This multicenter study examined the PK and probability of pharmacokinetic-pharmacodynamic (PK-PD) target attainment profile of i.v. minocycline in critically ill patients, with suspected or documented infection with Gram-negative bacteria.
Topics & Concepts
PharmacokineticsMinocyclineCritically illMedicinePharmacodynamicsPharmacologyIntensive care medicineAnesthesiaAntibioticsChemistryBiochemistryAntibiotics Pharmacokinetics and EfficacyBlood disorders and treatmentsAntimicrobial Resistance in Staphylococcus