Characterization of the pleural microenvironment niche and cancer transition using single-cell RNA sequencing in EGFR-mutated lung cancer
Yu‐Yuan Wu, Ya‐Ling Hsu, Yung‐Chi Huang, Yue‐Chiu Su, Kuan‐Li Wu, Chao‐Yuan Chang, Chai-Tung Ong, Jia-Chen Lai, Tzu-Yen Shen, Tai-Huang Lee, Jen‐Yu Hung, Ying‐Ming Tsai
Abstract
Taken together, our results highlight cell-specific mechanisms involved in the pathobiological development of pleural metastasis in lung cancer. These results provide a large-scale and high-dimensional characterization of the pleural microenvironment and offer a useful resource for the future development of therapeutic drugs in lung cancer.
Topics & Concepts
Cancer researchLung cancerMetastasisMalignant pleural effusionCancerMedicinePleural effusionEpithelial–mesenchymal transitionEpidermal growth factor receptorTumor microenvironmentBiologyPathologyInternal medicineCancer Immunotherapy and BiomarkersFerroptosis and cancer prognosisCancer Cells and Metastasis