Transcript-Activated Coatings on Titanium Mediate Cellular Osteogenesis for Enhanced Osteointegration
Omnia Fayed, Martijn van Griensven, Zeinab Tahmasebi Birgani, Christian Plank, Elizabeth R. Balmayor
Abstract
. Osteogenesis was confirmed using BMP2 cmRNA fibrinogen-coated Ti disks, and it was dependent of the cmRNA amount present. Alkaline phosphatase (ALP) activity of C2C12 increased when using fibrinogen coatings containing 250 ng of cmRNA or more. Similarly, mineralization was also observed that increased with increasing cmRNA concentration. Overall, our results support fibrinogen as an optimal material to deliver cmRNA from titanium-coated surfaces.
Topics & Concepts
OsseointegrationTransfectionFibrinCoatingBone morphogenetic protein 2Biomedical engineeringTitaniumChemistryMaterials scienceIn vitroBiophysicsImplantNanotechnologyBiochemistrySurgeryImmunologyBiologyMedicineOrganic chemistryGeneRNA Interference and Gene DeliveryBone Tissue Engineering MaterialsOrthopaedic implants and arthroplasty