Synthesis, crystal structures, anticancer activities and molecular docking studies of novel thiazolidinone Cu(<scp>ii</scp>) and Fe(<scp>iii</scp>) complexes targeting lysosomes: special emphasis on their binding to DNA/BSA
Jia Shao, Qiang Zhang, Jing Wei, Jing Wei, Zhiguang Yuchi, Peng Cao, Shaoqing Li, Shan Wang, Jing‐Yuan Xu, Shuang Yang, Yi Zhang, Jin-Xia Wei, Jin-Xia Wei, Jin‐Lei Tian
Abstract
by docking studies, and this suggested that the binding process was spontaneous. Complex 1 displayed a lysosome-specific targeting behavior with a Pearson coefficient value of 0.82 by confocal laser scanning microscopy (CLSM), and accumulated in the lysosomes, followed by the disruption of lysosomal integrity.
Topics & Concepts
ChemistryBovine serum albuminAgarose gel electrophoresisTriclinic crystal systemDNABinding constantFluorescenceCrystallographyHydrophobic effectMoleculeStereochemistryBinding siteCrystal structureChromatographyBiochemistryOrganic chemistryQuantum mechanicsPhysicsMetal complexes synthesis and propertiesProtein Interaction Studies and Fluorescence AnalysisLanthanide and Transition Metal Complexes