The Implication of Sphingolipids in Viral Infections
Sanya Thomas, Stephen Varghese Samuel, Annmarie Hoch, Caitlin Syphurs, Joann Diray‐Arce
Abstract
Sphingolipids are involved in cell signaling and metabolic pathways, and their metabolites play a critical role in host defense against intracellular pathogens. Here, we review the known mechanisms of sphingolipids in viral infections and discuss the potential implication of the study of sphingolipid metabolism in vaccine and therapeutic development.
Topics & Concepts
SphingolipidBiologyIntracellularSignal transductionCell metabolismViral infectionMetabolic pathwayCell biologyComputational biologyCellMetabolismVirologyVirusBiochemistrySphingolipid Metabolism and SignalingHIV Research and Treatmentinterferon and immune responses