Diallyl trisulfide inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung cancer <i>via</i> modulating gut microbiota and the PPARγ/NF-κB pathway
Zhuo Qu, Jiahui Tian, Jiachen Sun, Ying Shi, Jianqiang Yu, Wannian Zhang, Chunlin Zhuang
Abstract
, which has inhibitory effects on tumor growth. Mechanistically, DATS could activate the PPARγ pathway, leading to the negative regulation of the NF-κB signaling pathway and subsequent suppression of NF-κB-mediated inflammatory factors. Collectively, these findings provide support for DATS as a potential novel chemopreventive agent for tobacco carcinogen-induced lung cancer.
Topics & Concepts
NF-κBChemistryLung cancerPeroxisome proliferator-activated receptorGut floraNFKB1PharmacologyCancer researchSignal transductionBiochemistryMedicineReceptorInternal medicineTranscription factorGeneGarlic and Onion StudiesGenomics, phytochemicals, and oxidative stressSelenium in Biological Systems