Design, synthesis, and biological evaluation of pyrazole–ciprofloxacin hybrids as antibacterial and antibiofilm agents against <i>Staphylococcus aureus</i>
Ojaswitha Ommi, Priyanka Sudhir Dhopat, Shashikanta Sau, Madhu Rekha Estharla, Srinivas Nanduri, Nitin Pal Kalia, Venkata Madhavi Yaddanapudi
Abstract
A series of pyrazole–ciprofloxacin hybrids were designed, synthesized, and tested for antibacterial activity against Staphylococcus aureus , Pseudomonas aeruginosa , and Mycobacterium tuberculosis , aiming to combat antibiotic resistance.
Topics & Concepts
Staphylococcus aureusCiprofloxacinMicrobiologyPyrazoleChemistryBiologyBacteriaAntibioticsStereochemistryGeneticsAntimicrobial Resistance in StaphylococcusBacterial biofilms and quorum sensingAntimicrobial Peptides and Activities