Shining a FLASHlight on Ultrahigh Dose-Rate Radiation and Possible Late Toxicity
Amit Maity, Constantinos Koumenis
Abstract
A recent study reported results from a clinical trial in cats and from experiments in mini-pigs in which a single dose of radiotherapy was delivered at ultrahigh dose rates (FLASH). There was acceptable acute toxicity; however, some animals suffered severe late toxicity, raising caution in the design of future trials. See related article by Rohrer Bley et al., p. 3814.
Topics & Concepts
ToxicityDose rateMedicineToxicologyBiologyMedical physicsInternal medicineRadiation Therapy and DosimetryAdvanced Radiotherapy TechniquesRadiation Detection and Scintillator Technologies