Preparation and characterisation of PHT-loaded chitosan lecithin nanoparticles for intranasal drug delivery to the brain
Amal Yousfan, Noelia Rubio, Abdul Hakim Natouf, Aamal Daher, Nedal Al-Kafry, Kerrie Venner, Houmam Kafa
Abstract
, which was associated with a sustained release of PHT. These preliminary findings show that the IN delivery of PHT-loaded NPs is very promising for managing epilepsy. The direct nose-to-brain approach increases the safety margins of PHT, while the sustained release could improve patient compliance in a clinical setting.
Topics & Concepts
Nasal administrationLecithinChitosanDrug deliveryChemistryNanoparticleDrugPharmacologyChromatographyMedicineNanotechnologyMaterials scienceOrganic chemistryAdvanced Drug Delivery SystemsDrug Solubulity and Delivery SystemsAdvancements in Transdermal Drug Delivery